A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Applying solitary-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis pursuits include things like:
Human Rad51 filaments on double- and one-stranded DNA: correlating normal and irregular varieties with recombination function.
Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I
Our perform was speedily adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors comprised of one- and multi-walled carbon nanotubes in Utilized Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first ever examine from the dynamics DNA supercoils and the invention of supercoil hopping
Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: rapid electron relay to redox enzymes and zeptomole protein-film voltammetry
Given that 2000 he moved to single-molecule biophysics and nanobiology, with study from DNA supercoiling research of nucleosomes and DNA maintenance proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with micro organism on chip, although his ultimate desire is while in the path of knowing artificial cells.
2000, discovery that nanotubes can have remarkable substantial current densities; settled the controversial difficulty of electronic transport by DNA molecules by measurements of insulating behavior at the single molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
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But carbon nanotubes have remained a exploration subject matter of appreciable fascination to quite a few. In truth, the outlook on using carbon nanotubes to build practical devices, in locations like radio-frequency electronics, digital electronics and versatile electronics, stays vivid.
‘The concept that There may be this kind of factor like a starting, a major bang, is already an interesting signpost to take into account that there was a creator. But additional typically, and on The idea of pure rationality, I also get there in a Christian interpretation of fact. An atheistic worldview is usually a naturalistic worldview: essentially, there are only atoms and organic forces that we will evaluate.
Afterwards we spoke once more briefly due to the fact Dekker felt that our dialogue of his religion quickly became purely philosophical, whereas Additionally, it concretely will help him in his get the job done.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of long-selection conformational changes in Mre11/DNA mend complexes; and https://www.ceesdekker.net first pressure measurements with a DNA molecule within a nanopore
Reliable-condition nanopores have established being a amazingly multipurpose probe for one-molecule Investigation of DNA. I'll describe a number of our latest results – especially DNA knots – along with our attempts to broaden the capabilities of solid-point out nanopores even further more, during the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.